The Tsai-Fan Yu Memorial Lecture was presented by Professor Samual Waxman, Mount Sinai School of Medicine, New York. The Yu Lecture was a special contribute to a pioneering Chinese biomedical scientist who had contributed significantly to clinical research in the United States. He has authroed over 400 scientific publications, and has received numerous scientific awards. He is the founder of the Samual Waxman Cancer Research Foundation with over $75 millions USD endowment. He collaborates with many Chinese institutes in studies designed for advancing the understanding and treatments of cancers. His lecturewas entitled "Therapeutic Strategies to Overcome Oncogenic Transcriptional Repression.".
Dr. Tsai-Fan Yu was born in Shanghai, China, in 1911. As a sophomore in Gin Ling College, she was admitted into Peking Union Medical College (PUMC) with a full scholarship. She received her M.D. with highest honors and became Chief Resident of Internal Medicine at PUMC in 1939, an unprecedented distinction for a female physician during that era. In 1947, she came to New York City, where she first worked at Columbia University College of Physicians and Surgeons, and then joined the faculty of Mount Sinai Medical Center in 1957, where she spent the remainder of her professional career. She was Mount Sinai’s first female Full Professor in Internal Medicine, and retired with Professor Emeritus status in 1992 at the age of 81. In conjunction with Dr. Alexander Gutman, she performed the ground-breaking research on uric acid metabolism that turned gout into a treatable disease. Dr. Yu was among the first to demonstrate that gout could be effectively controlled with allopurinol. In another seminal study, she showed that colchicine could prevent gouty attacks. She served as a member of the National Institutes of Health (NIH) advisory panel on metabolic diseases, and her research was continuously funded by the NIH for 26 years. She received numerous honors and awards throughout her career, including the Distinguished Career Achievement Award from Mount Sinai Medical Center and the Master Award from the American Association of Rheumatology. Her ability to translate laboratory research into the effective prevention and treatment of gout represents a milestone in medicine. As a clinician she followed over 4000 active gout patients, probably one of the largest gout-based practices that ever existed. Dr. Tsai-Fan Yu’s pioneering and seminal contributions to elucidating the metabolic basis and defining treatments for gout are a paragon of translational biomedical research.